药学专业本科毕业论文题目示例：
Title: The Effect of Estrogen on the Expression of Drug Transporters in Human Prostate cancer cells
Abstract:
The study aims to investigate the effect of estrogen on the expression of drug Transporters in human Prostate cancer cells. Estrogen is a key factor in the development and progression of Prostate cancer. The expression of drug Transporters, which play a crucial role in drug metabolism and transportation, is crucial in the treatment of Prostate cancer. The study found that estrogen regulated the expression of drug Transporters in human Prostate cancer cells. This regulation was associated with the increased sensitivity of the cells to drug therapy. The study provides new insights into the potential therapeutic applications of drug Transporters in Prostate cancer and suggests that estrogen may be a potential therapeutic target for the treatment of Prostate cancer.
Keywords: Prostate cancer, drug Transporters, Estrogen, therapeutic potential.
Introduction:
Prostate cancer is a common cancer in men and is one of the leading causes of cancer-related death in the United States. Estrogen is a key factor in the development and progression of Prostate cancer. Estrogen can promote the growth and survival of Prostate cancer cells, and can also increase the sensitivity of the cells to drug therapy. The expression of drug Transporters, which play a crucial role in drug metabolism and transportation, is crucial in the treatment of Prostate cancer. The study aims to investigate the effect of estrogen on the expression of drug Transporters in human Prostate cancer cells.
Methods:
The study used human Prostate cancer cells (PC-3 and Du145) and human悉铭大厦 (H悉) as a control. The cells were grown in flasks and were exposed to estrogen for various periods of time. The expression of drug Transporters was measured using RT-PCR and Western blotting. The effect of estrogen on the sensitivity of the cells to drug therapy was measured using the cell death analysis method.
Results:
The study found that estrogen regulated the expression of drug Transporters in human Prostate cancer cells. Estrogen increased the expression of drug Transporters such as P-精氨酸氨酸氨基转移酶 (P-Tac), P-葡萄糖醛酸转移酶 (P-Ggt), and P-葡萄糖酸内酯酶 (P-Ggt1) in a time- and concentration-dependent manner. The expression of these drug Transporters was associated with the increased sensitivity of the cells to drug therapy. The study also found that estrogen had no significant effect on the expression of drug Transporters in human悉铭大厦 (H悉) cells.
Conclusion:
The study found that estrogen regulated the expression of drug Transporters in human Prostate cancer cells. This regulation was associated with the increased sensitivity of the cells to drug therapy. The study suggests that estrogen may be a potential therapeutic target for the treatment of Prostate cancer. However, further research is required to understand the potential mechanisms underlying the regulation of drug Transporters by estrogen in Prostate cancer.
Keywords: Prostate cancer, drug Transporters, Estrogen, therapeutic potential.